The Involvement of Serotonin in Canine Aggression
5-hydroxytryptamine (5-HT), is a monoamine. Its adjective is
Chemically, Serotonin is created in seratonergic neurons in the CNS.
Serotonin is synthesized from tryptophan by the enzyme tryptophan hydroxylase (TPH), which produces 5-hydroxytryptophan (5-HTP) and then the action of 5-HTP decarboxylase to create 5-HT.
Sertonergic neurons are mostly found in the raphe nuclei of midbrain, pons and medulla.
There are nine types of seratonertic receptors with varying effect, for example 5-HT1B and 5-HT1D are presynaptic autoreceptors. All receptors are metabotropic, except for the ionotropic 5-HT1A.
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