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          Canine Heart Disease          

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Cardiac Diseases
Heart Disease
Heart Muscle Diseases
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Cardiac Diseases of Cats and Dogs

David Tayman, D.V.M.
www.petshealth.com

Listed below are several of the more prevalent cardiac diseases of cats and dogs. This is article is intended to be used as a summary of some of the common cardiac diseases. The article was not written by a cardiologist and is for general knowledge only. Please consult with your veterinarian for any cardiac conditions diagnosed.

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The heart is a muscular organ consisting of four chambers- a right and left atrium and right and left ventricles.(fig. canine heart, feline heart) Valves are located between the atrium ,ventricles, and the two major vessels leading to the heart to prevent blood from flowing abnormally. Blood is circulated through the body by the pumping action of the heart. Deviations in the size of the chambers, or strength or elasticity of the muscle, or disease of the valves, will affect the flow of blood in the body and subsequently the dynamics of all the organs in the body. Once the heart begins to malfunction a vicious cycle develops and abnormal fluid build-up begins in different areas of the body depending on which side and part of the heart are involved. Thus, congestive heart failure develops. Listed below are several common heart diseases of both cats and dogs.

CARDIOMYOPATHY IN CATS
Dilated cardiomyopathy is a disease of the ventricular muscle, characterized by a loss of muscle tone of the heart. The heart loses its strength and tone and becomes enlarged, filled with blood and unable to contract properly. Before the mid 1980's this was one of the most commonly diagnosed heart diseases of cats. Most cats probably had secondary cardiomyopathy as a result of taurine deficiency. Due to changes in diet formulation, this is now an uncommon cause of heart disease in cats. There may also be a genetic component in Siamese, Abyssinian, and Burmese cats. Clinical signs are related to low cardiac output: loss of appetite, weakness, depression, difficulty breathing, and thromboemboli causing painful paralysis. Diagnosis is made by x-ray and ultrasound. Ultrasound is the definitive diagnostic tool.

Treatment is that of congestive heart failure, with the use of digoxin, diuretics such as furosamide, and supplementation of taurine. Prognosis is poor despite intensive therapy.

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Hypertrophic cardiomyopathy: (fig. Hypertrophic Cardiomyopathy)
Hypertrophic cardiomyopathy is a thickening of the heart muscles causing a decrease in the size of the chambers of the heart. As a result, the heart cannot supply the body the amount of blood it needs due to the decreased volume of blood in the chambers. Hypertension develops and pulmonary edema (fluid in the lungs) develop. Congestive heart failure, thromboemboli, and abnormal heartbeats (arrythmias) develop. Clinical signs include difficulty breathing, loss of appetite, exercise intolerance, vomiting, collapse, or sudden death, . In the early stages the physical exam is normal. We have observed sudden death in some kittens and cats during routine anesthetic induction. Post mortem exam reveals cardiomyopathy as the cause of death. This is similar to the sudden death seen in some young athletes. Physical signs seen during exams in cats with more developed cardiomyopathy include an abnormal heart- beat, murmur, muffled heart sounds, rapid heart sounds, difficulty breathing, weakened pulses, and early stages of hypertension. Differential diagnosis includes that of hyperthyroidism, valvular disease, hypertension, trauma, feline asthma, and cancer of the chest. Diagnosis is based upon x-ray and, most importantly, ultrasound.

Treatment is palliative. In people, heart transplant is the treatment of choice. In cats, we treat with low sodium diets, medications to treat congestive heart failure such as diltiazem, or atenelol, and aspirin to prevent blood clots. Diuretics may also be used. Low salt diets may be used, but palpability may be an issue. The prognosis varies from good to poor depending upon the severity of the disease.

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Restrictive cardiomyopathy of cats:
This is a poorly defined heart disease involving selected areas of the ventricles of the heart. Scarring of the heart muscle results in both contraction and relaxation difficulties of the heart leading to congestive heart failure. Cats with restrictive cardiomyopathy have clinical and functional signs similar to both of the other forms of cardiomyopathy. Dilatation of all cardiac chambers may be evident. Signs are those of congestive heart failure-poor appetite, weight loss, difficulty breathing, blood clots and paralysis of the limbs. Differential diagnosis is that of hypertrophic cardiomyopathy, dilated cardiomyopathy, hyperthyroidism and hypertension . Diagnosis is confirmed by ray, disproportionate atrial enlargement, abnormal lung shadows, and ultrasound. Ultrasound might show an abnormal right atrial enlargement and other changes too complex to discuss on this handout. Treatment includes diuretics, nitroglycerine application, calcium channel blockers,such as diltiziam, and possible use of beta blockers, such as atenelol. The diuretic furosamide may also be recommended as well as low dose aspirin. Low salt diets are recommended, but as stated above palatability may be an issue.

Most cats with restrictive cardiomyopathy live for 3-12 mos.

CARDIOMYOPATHY IN DOGS
This is a flaccidity of the heart muscle similar to cats. The heart cannot pump properly causing congestive heart failure. There is a suspicion that this may be a genetic disease. We see a breed predilection in the Doberman pincher, boxer, giant breeds i.e. Irish wolf hound, Scottish deer hound, great dane. We also see a taurine related dilated cardiomyopathy in cocker spaniels. Clinical signs are difficulty breathing, weakness, coughing, weight loss, abdominal distension, fainting, and sudden death. Exam findings include decreased pulses, abnormal heart sounds and beats, muffled heart sounds, murmurs. Diagnosis is based upon x-ray and ultrasound. Treatment for congestive heart failure include treating with ACE inhibitors, such as enalapril, digoxin, and the diuretic furosamide and low salt diets. Evidence suggests that the nutraceuticals supplements taurine and carnatine as well as Co enzyme Q 10 may be of help. The prognosis is poor.

In our practice we recommend that all American cocker spaniels be placed on taurine as puppies and continued for life.

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 Hypertrophic cardiomyopathy of dogs:
This is a rare disease of dogs caused by a thickening of the heart musculature. Due to the thickening of the heart muscle, the size of the heart chamber is smaller resulting in decreased ability of the heart to pump blood to the rest of the body. This disease has been described in dogs of all ages. Signs range from asymptomatic to those of congestive heart failure, including heart murmur, difficulty breathing, coughing, and exercise intolerance Diagnosis is best made with x-ray and ultrasound Treatment includes rest, low salt diets, diuretics such as furosamide, beta blockers such as atenelol or propanolol or calcium channel blockers such as diltiziam. People with hypertrophic cardiomyopathy improved symptomatically when given verapmil on a long term basis. Low salt diets may be recommended.

The prognosis is poor.

Valvular diseases
The heart contains four valves: - mitral valve (left AV)- the valve between the left atrium and left ventricle - tricuspid valve (right AV)- the valve between the right atrium and right ventricle - aortic or left semilunar valve-the valve between the left ventricle and aortic valve - pulmonic or right semilunar valve-the valve between right ventricle and the pulmonary artery

Valve dysfunction occurs by either congenital or acquired heart disease. The clinical finding of valvular disease is a cardiac murmur.

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Types of valvular disease:

Endocardosis - This is a degenerative disorder and occurs most frequently in dogs and usually involves the mitral valve.
 
Congenital Aortic Stenosis - Congenital pulmonic valve stenosis Bacterial endocarditis Valvular disease due to cardiomyopathy
 
Diagnosis is made by clinical signs, auscultation (listening to the heart), xray, ultrasound as the definitive diagnostic tool. Treatment is based on the type and severity of the valvular disease. Currently, treatment of asymptomatic dogs is not recommended unless changes of the heart size are observed on x-ray. As the severity of the disease progresses, diuretics, low sodium diets, digoxin, and vasodilator therapy is begun. In most cases the vasodilator can be an ACE (angiotension-converting enzyme) inhibitor. Furosamide is usually the diuretic first administered. The use of digoxin in dogs with valvular disease is somewhat controversial. Most cardiologists now advocate its use in mild cases of heart failure. It is most definitely used if arrhythmias (abnormal heart beats) are present and if advanced heart failure is present. There are many other vasodilators available for use such as hydralizine, prazosin, and diltiazem to name a few. Your veterinarian will prescribe the medication and regimen they are most familiar with.

 Pericardial Diseases and Cardiac Cancer:
The pericardium is a sac that surrounds the heart and serves to protect the heart and major vessels. When diseased it can cause life-threatening restriction of the ventricles. Pericardial effusion (fluid in the sac) is the most common type of pericardial disease. This may result from infection, congestive heart failure, hemorrhage due to trauma or cardiac rupture, or cancer. Clinical signs may be absent and only detected by auscultation . Your veterinarian may hear muffled or displaced heart sounds. Other signs include vomiting and difficulty in breathing. Diagnosis is based upon physical exam, x-ray, and ultrasound. Ultrasound is the most effective for diagnosis the effusion and for detecting pericardial and cardiac masses. Treatment involves relieving the cardiac compression by removing the fluid with a needle placed into the sac. Surgery may be required. The prognosis is based upon the underlying cause.

Thrombosis:
Thrombosis is a blood clot in a vessel obstructing blood flow. The diagnosis is based upon clinical signs, index of suspicion, and use of a doppler to measure blood flow in certain situations.

Treatment includes removal or disintegration of the clot, controlling the underlying disorder, and supportive care to damage tissues. The prognosis is poor.
 
Congenital heart diseases:
Congenital heart disease is the most common heart disease in animals less than one year of age. The scope of this article is to list these diseases. Please consult with your veterinarian or a veterinary cardiologist regarding these diseases. These include patent ductus arteriosis, subvalvular stenosis, pulmonic stenosis, valvular dysplasia, atrial and ventral septal defects, and pericardial diaphragmatic hernias. Signs include that of congestive heart failure. Diagnosis is based on physical exam as a puppy or kitten. Auscultation may reveal a murmur. X-ray and ultrasound as well as angiocardiography (dye injection) are more definitive as to the type and severity of the disease Treatment- Referral to a cardiologist is the best course of treatment.

Arrhythmias (abnormal heart beats) are also diseases found in both cats and dogs and are beyond the scope of this article.
Thanks to Hill's Prescription Diets for the illustrations
Columbia Animal Hospital @ Hickory Ridge
10788 Hickory Ridge Road - Columbia, MD 21044
ph: 410-730-2122 - ph: 301-596-5549 - fax: 410-992-9511

e-mail: info@petshealth.com
reprinted with kind permission from
David Tayman, D.V.M. www.petshealth.com

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Heart Disease in Dogs, Cats, and Other Pets  

www.animalpetdoctor.com

by Roger Ross, DVM

It surprises some owners that heart disease is common in cats and dogs...just like in humans.  And just like in humans, the heart is a mechanical-electrical pump made out of living tissue and is prone to not only to all the biological hazards affecting cells, but also to all kinds of mechanical, stretching, leaking, and electrical mishaps, pressure problems, clogs, and disasters that affect non living tissue.

Unlike with diarrhea or skin problems, most pet owners don't know or even suspect their pet has heart disease, but veterinarians often detect the problem during routine physical exams early enough to make a wonderful difference to the longevity and well being of the pet.

This is one of several major reasons for making sure your pet has a good check up at least once a year.

Your veterinarians will also suspect or detect heart disease when your pet is brought in for

coughing or hacking

wheezing

decreased energy or stamina

edema 

abdominal bloat

signs of poor cirulation

Sometimes your vet will pick up on early heart disease even when there are no obvious symptoms yet because you're the wonderful type of pet owner that allowed your vet to spend a little extra for pre-anesthetic blood work and/or EKG monitoring prior to and during a surgery or dental cleaning procedure that was needed.

And, of course, heartworm disease ... the most common type of heart disease... is frequently detected long before obvious symptoms occur because of the routine testing done in just about every clinic in those parts of the country where heartworm is prevalent.

One last introductory comment:  Just like in humans, heart disease is associated with genetic factors but also with

Obesity

Lack of Exercise

Poor Diet

What To Expect When You Take Your Dog To The Vet For Heart Disease

Exam and History:
There are lots of clues on history such as being tired after a little bit of exercise, coughing after exercise and so forth.  

We will be giving your pet a good general exam that will include listening carefully to your pet's heart and lungs, feeling the quality of the pulse, checking the color and nature of the mucus membranes, checking the tiny vessels in the eyes, palpating the abdomen, and maybe rechecking everything after exercise.

We will also be asking a lot of questions that will help us with the diagnoisis and hopefully prevent us from going down some expensive false trails.  (such as mistaking indigestion for heart disease and vice versa)


It's interesting that certain breeds are more likely to have certain types of heart disease:

Murmers:  Cockers, Poodles, Schnauzers, Dachshunds, Chihuahuas, Pomeranians, and Min. Pinschers

Myocarditis:  Boxers, St Bernards, and German Shorthair Pointers

Cardiomyopathy:  large breeds of dogs

Heart base tumors:  Boston Terriers, Boxers, and English Bulldogs

Various Congential Heart Problems:  Poodle, Collies, Poms, Sheperds, Eng. Bulldogs, Schnauzers, Pointers, Keeshonds, Fox Terriers, Irish Setters, and Weimaraners.

Once heart disease is suspected, your vet will discuss and offer and least some of the following laboratory and imaging choices:

A.  Rule out heartworm disease with an elisa test: 

B.  CBC and Chemistry;  this is important because so often heart disease is seen in association with other diseases...especially kidney and liver diseases. 

C.  Radiographs; to see if the heart is enlarged typical of certain types of heart disease, to see if there are tumors, to see if the lungs are very congested, and to see if there is fluid around the heart. 

D.  Urinalysis:  This test is not likely to tell us anything specific about the heart, but it's included in the work up of  pets suspected of serious disease. 

Why?  Because most serious diseases also involve other organ systems and this fairly inexpensive test of urine gives us a good feel for the heatlh of the kidneys and bladder as well as hints about pancreatic, liver, and gall bladder health.  It helps with our asscessment of tissue hydration too.

E.  EKG:  EKG's help us rule out cardiac blocks and arrthymias, electrical conduction problems of the heart, and also are pretty good at indicating cardiac enlargement.

If your vet, like me, is not expert at reading EKG's...or chest x-rays, for that matter, with the modern miracle of the digital age, we can have an expert read your pet's EKG or X-ray from a remote location through the phone lines!

F.  Echo, Ultra Sound, Angiograms, MRI's, Cat Scans, and other types of Imaging:  All this is now available in veterinary medicine, although usually a trip to a specialist facility is necessary.

As you might suspect, while many heart problems can be greatly improved with inexpensive medicine and nutritional support, the best available testing and treatment for heart disease can be quite expensive.

I mention this for three reasons:

  One:  To prepare you to think realistically.  Heart disease is fairley common and often stikes without much warning.

  Two:  To motivate you to take the trouble and relatively minor expense of providing a good lean diet, lots of exercise, and heartworm preventive.

  Three:  To consider Pet Health Insurance.  It sure is nice to have when your beloved pet needs it.

Once a Tentative Diagnosis is Made, your vet will discuss these treatment options:

1.  Consider referral to a specialist for heart disease...Your vet will give you an honest accessment of his or her skill level in treating any serious disease.  Don't expect your general practioner to be an expert in everything...especially a complex disease like heart disease where highly specialized equipment is often needed and where new, potentially dangerous, medications are frequently being introduced.

2.  At our clinic,  if  you elect to let me treat your dog after making a tentative diagnosis of heart disease, here's what we'll consider trying:

A.  Nutritional support.  We'll recommend taking advantage of one the several superior diets made especially to minimize cardiac problems.

B.  Weight Loss if appropriate...Many heart disease patients are way too fat.

C.  Furosimide tablets as needed to control coughing and congestion.  This is a diuretic and will make your dog urinate and drink more but often works well in relieving the fluid load in the lungs associated with heart disease.

D. Digoxin tablets:  this poison, given in tiny amounts helps improve cardiac function.   This medication is not tolerated by many pets (causes nausea etc), so we will start out with a small dose and work up.

E.  Blood Pressure tablets:  Ace Inhibitors (Enalapril or  Captopril)  greatly reduce the work load of the heart by  causing dilation of the blood vessels.  Possibly dangerous if your pet also has kidney disease.  Another reason to do blood work and an urinalysis to check other organ systems.

F.  Potassium or Multivitamins; loss of potassium is a problem with both heart disease and the medications used to treat heart disease.

G.  Aspirin; small amounts help prevent secondary problems such as blood clots that are sometimes part of the cardiac disease syndrome.

The aspirin dose we will be recommending is small enough that problems such as GI inflammation is not likely.

H.  Beta Blockers decrease outflow obstruction common in heart disease and are often recommended by cardiac specialists, especially in cardiomyopathy.

I.  CoEnzyme Q10:  a neutriceutical highly touted by the people that sell it for improving cardiac and vascular health.  CoEnzyme Q10 does seem to be helpful, but beware that it hasn't been accepted yet as safe and effective by cardiac specialists, the FDA, etc.

It's hard to get approval in the medical industry for neuticeuticals and despite lots of testimonials for these medications it's very hard to get honest information about them.  I'm presently a believer in the usefulness of CoEnzyme Q10  but based on pretty flimsy medical evidence.  (See my comments on the neutriceutial business in the medication section of this site.)

Despite these warnings, supplementation with coenzyme Q10 has resulted in dramatic increases in cardiac contractility in humans with cardiomyopathy. Coenzyme Q10 is a member of the electron transport chain essential in myocardial energy production. Clinical trials examining the efficacy of coenzyme Q10 in the dog are underway.

J.  Frequent rechecks.  Heart disease and the medications used to treat heart disease both merit frequent rechecking and adjusting. 

K.  Again...consider referral.  Especially if results are poor.

Heart Disease in Dogs

"When it comes to heart disease, regular visits to your veterinarian could mean the difference between life and premature death," says Joanne Bicknese, DVM, Manager, Technical Services for Merck AgVet, the animal health division of Merck & Co., Inc. "Dog owners may not realize that their pets are susceptible to many forms of heart disease. In most cases, heart disease can be successfully managed with early detection and treatment".

Heart Failure
One major threat to your dog's health is heart failure. Of the dogs in the United States examined annually by a veterinarian, approximately 3.2 million have some form of acquired heart disease and may be in heart failure.

Heart failure results from the heart's inability to pump blood at a rate required to meet the body's needs. While continuing to work harder to pump blood, further heart damage can occur.

Although some of the early stages of heart failure in dogs have no visible signs, heart failure can be diagnosed through a clinical evaluation by a veterinarian. Dogs with mild to moderate heart failure typically experience heart enlargement, coughing, lethargy and difficulty breathing.

Severe heart failure is characterized by difficulty breathing (even at rest), fainting, profound intolerance to exercise, loss of appetite and weight loss.

"Too often, dog owners do not take their dogs to visit the veterinarian until they are displaying severe signs of heart failure, and by then it may be too late," says Dr. Bicknese.

"When heart disease is detected in your dog, your veterinarian can recommend a schedule of regular visits and discuss a treatment plan that can help."

Overall Good Health
In addition to safeguarding your dog's heart, there's a lot you can do to keep your dog happy and in top shape. Ensure that your dog gets a moderate amount of exercise on a regular basis and has a balanced diet. An obese dog may have a harder time staying healthy.

Avoid the heartbreak of seeing your family's best friend fall ill. Proper care and veterinary supervision can help you watch your dog grow to a "hearty" old age.

Remember that this information is not intended to be a substitute for taking your beloved pet to your veterinarian. 
It takes experience and the right tools of the trade to determine whether a problem is likely to respond to simple treatment and a little love or require a full medical commitment to save the patient.not only is this information not intended to help you treat serious pet health problems at home; I am hoping these pages will reinforce your awareness to just how complicated and variable diagnostic and treatment choices can be. Veterinary Medicine is a bargain; take advantage of it.


foxnest@metacrawler.com   Thanks, Roger Ross, DVM
reprinted with kind permission from Roger Ross DVM
www.animalpetdoctor.com


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Heart Muscle Diseases

http://www.gopetsamerica.com

Diseases of the heart muscle are less common than disorders of the valves. Dilated cardiomyopathy is, however, the second most common from of canine heart disease. Hypertrophic cardiomyopathy, although a common condition in cats and people, is rare in dogs; so, too, is myocarditis. The risk of heart diseases is inherited, particularly in certain breeds. It can be reduced by breeding from dogs whose families are free of disease.

DILATED CARDIOMYOPATHY
This condition, also called DCM, affects relatively young dogs, usually under 7 years old, and sometimes as young as 2 years of age. In Cocker spaniels it may be associated with hypothyroidism, a condition in which a dog's own immune system attacks the thyroid gland, resulting in diminished thyroid hormone production. DCM may also be associated with immune system in the Doberman Pinscher. The breeds most commonly affected include the Boxer, Doberman Pincher, Irish Wolfhound (all high-risk), and also the Afghan Hound, Great Dane, Old English Sheepdog, and St. Bernard. The condition now is also being diagnosed in smaller breeds, including Cocker spaniels and Dalmatians. DCM affects more males and females.

Affected dogs are lethargic, tire easily from routine exercise, and often go off their food and lose weight. They may have a cough, especially at night. Congestive heart failure develops; as a result, fluid accumulates in the lungs and/or in the belly, causing the abdomen to swell. Both Boxers and Dobermans may die suddenly without showing any previous signs of illness.

Diagnosis
An ECG will show changes in the heart's rhythmic contraction, while a chest X-ray will reveal that that the heart has become enlarged and dilated (expanded). Echocardiography will confirm that the heart wall is thin and the heart chambers are enlarged.

Treatment
The dog is given treatment for congestive heart failure. Diuretic drugs such as spironolactone or furosemide diminish the buildup of fluid in the lungs and abdomen, while ACE inhibitors and a new drug, pimobendan (Vetmedin), improve the heart function and circulation. There is nutritional logic in supplementing the diet with taurine and L-carnitine, although the benefit of these nutrients is still being studied. The long-term outlook for an affected dog is rather poor, although the use of pimobendan has increased survival time threefold in Doberman Pinchers.

HYPERTROPHIC CARDIOMYOPATHY

In this condition, the heart wall becomes thickened. It usually affects the ventricles (the lower chambers of the heart). As the muscle thickens, it reduces the space inside the heart for blood. The most common sigh is reduced exercise tolerance.

Diagnosis and Treatment
Hypertrophic cardiomyopathy is diagnosed by echocardiography. Treatment with the calcium channel blocker drug diltiazem appears to prolong life expectancy. strenuous exercise should be avoided.

MYOCARDITIS
This rare inflammation of the heart muscle has many possible causes. When canine parvovirus infection first occurred, the virus caused a fatal form of myocarditis in puppies, but this cause is now extremely rare. Other causes of myocarditis include canine distemper virus; Lyme disease; other viral and bacterial infections; and trauma.

Diagnosis and Treatment
Clinical signs of myocarditis include lethargy, fainting and heart rhythm disturbances. The treatment for this condition is similar to that for congestive heart failure.


©2003-2007 Go Pets America, Inc. All Rights Reserved.
reprinted with kind permission from Ethan
The Go Pets America Team
http://www.gopetsamerica.com
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 The above information is simply informational. It's intent is not to replace the advice of a veterinarian nor to assist you in making a diagnosis of your pet. Please consult with your own veterinarian for confirmation of any diagnosis. Your pets life may depend on it.