demodex

DEMODEX IN THE DOG

...and a case of Human Demodex
by T. J. Dunn, Jr. DVM
http://www.thepetcenter.com

Demodex in the dog is a common infestation of the dog’s skin with tiny, cigar-shaped, eight-legged mites. Human demodex cases do occur but transmission from the dog to a human is quite rare. Nevertheless, human cases of demodex do happen where transmission from a family pet to a human occurs. (See a case of demodex in a human below.) The mites reside and feed in the hair follicle and oil glands of the skin. Also called Mange, which is a general term used to describe any kind of mite infestation, Demodex is generally less severe than Sarcoptic mites (often called scabies).
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Fortunately, most cases of Demodectic mites are self-limiting… that is, the animal is able to arrest the reproduction and growth of the mites and eventually repair the damage they do. Once eliminated, most dogs do not acquire another infestation; the dog’s immune defenses are primed to eliminate any new Demodex mites that happen to find themselves on the dog. However, there are certain individual dogs that, because of genetic programming, do not produce the specific immune factors that will target the mites for destruction. That demodex2

specific lack of adequate immune defense against the mites is a hereditary aspect of the disease that can predispose an infested dog to a severe, unresponsive case of Demodex. Many veterinarians believe that all dogs have small numbers of Demodex mites residing in the skin and that having a few mites is normal and common. It is when immune related, or nutritional or environmental stresses impact the dog that visible skin lesions from mite infestations become noticeable. Seen most commonly in young dogs, and rarely in cats, Demodex skin lesions are usually transient, but occasionally in certain individuals the mites will totally overwhelm the dog's skin. See the photo below of a year old Doberman Pinscher with severe, generalized Demodicosis that was totally unresponsive to all attempts at treatment. Adult-onset Demodicosis is explained below.

The images below on the left and right are photos that when clicked on will open in a new window for a close-up look. In the center below you can view a video through a link to YouTube.com of a demodex mite that was taken from a skin scraping of an affected dog.
	View a live demodex mite through the microscope, just as if you were the veterinarian looking for this skin parasite. The video open on YouTube.com in a new window so you can close that window when finished viewing the video and be right back here. See the video!

QUESTION: Can Demodex mites be inherited?
ANSWER: No. The mites are not present on the fetus while the fetus is developing from an embryo in the uterus. However, if the mother has Demodex mites present in/on her skin, the mites can invade the new fetus’ skin immediately after birth. Since many dogs have Demodex mites present in their skin, and never actually develop noticeable skin lesions, the mother may not even be showing any signs of mites and yet transmit mites to the newborn pups. The pups may or may not develop a clinical case of mites.

QUESTION: Why, then, do I keep hearing that Demodex can be inherited.
ANSWER: The problem is the wording. The specific antibodies that will defend against infestation of Demodex can be inherited and most dogs have those immune factors and are able to defend against Demodex. But some individuals have inherited a deficiency of those antibodies and just don't have the ability to fend off the mites. So the ability to resist the mites, or not resist, is inherited. The actual mites are not inherited.

QUESTION: So if I have a pup that has Demodex and it is only six weeks old and has never been in contact with any dogs demodex4

outside our home, the mites must have come from the mother. But the mother has never had Demodex so how could that happen?
ANSWER: Your assumption that the mother dog has "never had" Demodex is probably not valid. Demodex mites have been proven to inhabit the hair follicles of many, many dogs, humans and other mammals without causing the host any problems at all. So these mites can be present in normal and healthy individuals (who have inherited the immune factors needed to keep the mites suppressed). So just because you have not experienced a visible skin lesion on your dog does not mean that the dog has no mites present.

QUESTION: If I have a dog that has Demodex, does that mean I should not breed it?
ANSWER: If the dog, male or female, has a protracted, difficult-to-cure case of Demodex, that dog should not be bred. If you have a dog that has or had a brief, localized episode of Demodex and has recovered well, then breeding may be considered; but some veterinarians believe that any dog that has displayed skin manifestations of Demodex should be removed from a high quality breeding program.

I asked David Senter, DVM, of Englewood, Colorado, a Board Certified Specialist in Veterinary Dermatology, the next question because there seems to be quite a bit of confusion regarding this issue. Dr. Senter specializes in the diagnosis and treatment or management of all skin, ear and nail diseases in animals. Below is his response...

QUESTION: If a young dog has been diagnosed with Demodex, is it best NOT to spay or neuter the dog until the Demodex has been cleared up?
ANSWER: From Dr. Senter: "Most dermatologists will elect not to treat a dog with generalized demodicosis unless it has been

spayed or neutered. The reason for this is simply due to the high likelihood of the affected dog's offspring to develop demodicosis. There is absolutely no benefit to NOT spaying or neutering a dog undergoing treatment. On the other hand, reproductive hormones in female dogs in heat (estrus) or in pregnant dogs can cause worsening of the mites or make it more difficult to control them. However, the presence of male reproductive hormones (un-neutered males) makes no known difference in the ability to control the Demodex mites. On a different note: I do not treat dogs with localized demodicosis (less than six affected spots) because more than 90% of them will resolve on their own. By treating them, you will never know if the patient would have become a generalized case or not.

QUESTION: Is Demodex transmissible to my healthy dog from a dog that is infested?
ANSWER: Healthy dogs are quite resistant to infestations and, as mentioned, may already have a number of mites residing harmlessly in the skin. It is best, though, to not allow your dog to have direct physical contact with a dog that has an active case of Demodex... just to be safe.

QUESTION: What about the dog that suddenly develops Demodex later in life and never had it as a puppy?
ANSWER: This is called Adult-onset Demodicosis and is most commonly seen in what are assumed to be healthy dogs but that in reality are actually affected with an underlying pathology or immune compromising disorder. Therefore, whenever a veterinarian is presented with a case of Demodex in an adult dog the doctor is alerted to the possibility that there is a potentially serious underlying disease going on that has compromised the dog's immune integrity. Such afflictions as cancer, Hypothyroidism, Systemic Fungal Disease,

DIAGNOSIS
Demodex mites usually create irregularly shaped, mildly irritated areas of hair loss. The skin is usually not inflamed and the demIW

The diagnosis is made by doing a skin scraping of the affected area and placing the scrapings on a microscope slide. Click here to see how a skin scraping is done. Usually the material scraped from the skin is mixed with mineral oil and then examined under the microscope. (NOTE: Sarcoptic mites are rarely visible via skin scrapings and are therefore very commonly misdiagnosed as an allergic skin disorder because the veterinarian "couldn't see any mites". See this article for important information about Sarcoptic Mites.) Demodex mites are plentiful and seem to be easily detected via skin scrapings even though they spend most of their time deep in the hair follicles.

HUMAN DEMODEX
Human demodex cases are rather rare but do occur. It is believed that demodex mites are a common residents of hair follicles in dogs and humans, and when present in few numbers in a healthy individual seldom cause clinically observable cases. Under certain unknown conditions, though, humans can develop clinical cases of demodex mites. The images below are of an animal caretaker who became infested in the facial regions with demodex mites. She had been providing the dog with prescribed treatments in the animal hospital. After consulting with a human dermatologist she was eventually able to eliminate the mites but the process entailed numerous topical treatments and also systemic medications. After six months of treatment, all symptoms of the mites disappeared.

Demodex in a human is presented. The Irish Wolfhound in the image below-left had a resistant case of mites and therapy covered many months before the dog was clear of any demodex parasites. One of the many individuals who handled this dog one became infested with the mites and displayed lesions on the face and neck. Therapy for this individual took months before a successful resolution of the problem was evident. Click on an image to enlarge.

TREATMENT
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In dogs with very mild, localized, small skin lesions some veterinarians do not treat the dog at all. Other veterinarians will always treat a Demodex lesion with topical medications appropriate as an insecticide. (Some home remedies are harmful so always consult with your veterinarian about any kind of skin lesion and the safest and most effective therapy.) These organisms are live parasites so applying such remedies as Vitamin E cream or aloe vera will have no effect on them.

It is vitally important that all dogs (not just dogs with health problems) be consuming a high quality, demdog3

meat-based diet with proper amounts of high quality fat. Any dog, especially a growing pup, that is consuming a cheap, grain-based diet will not fare as well as the dog eating a high quality diet. In general, the better diets are higher in price so do not let your decision about what to feed your dog be dictated by the cost. The nutritional aspects of skin disorders is an often overlooked "treatment" and should always be considered when a health impacting situation is present. For good information about nutrition, visit this department for a list of articles.

Mitaban was a commonly used treatment for Demodex and had a proven record of successes. This prescription-only product is diluted with water and applied to the dog's skin according to the product directions. Repeated applications are almost always required. This product may no longer be available. On occasion a veterinarian may decide to use a product called Ivermectin. This product must be very carefully calculated regarding dosages that are effective and not toxic. The use of Ivermectin in treating Demodex needs to be discussed with the owner prior to use since it has not been labeled for use against Demodex. Another treatment that is sometimes used is oral milbemycin given daily for six to eight weeks. Lime-Sulphur dips have been used in the past and some veterinarians continue to prefer this therapy for demodex. Ivermectin in fairly high doses is also used... with owner's consent and with caution!

The dog in this image (a Doberman Pinscher) was severely affected by Demodex skin mites from a very young age. The entire dog was affected. After a year of intensive treatment with dips, Revolution, Ivermectin, Mitaban, antibiotics, vitamins and other remedies, the unfortunate dog was finally euthanized. No treatment or combination of treatments had any affect on the state of the dog's health. Dietary and alternative treatments were attempted but probably because of genetically programmed immunity factors this patient was unable to ward off the parasites and progress to healing.

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The above information is simply informational. It's intent is not to replace the advice of a veterinarian nor to assist you in making a diagnosis of your pet. Please consult with your own veterinarian for confirmation of any diagnosis. Your pets life may depend on it.